Release date:2021/9/17 17:29:07
We report the design and synthesis of a series of three-dimensional (3D) covalent organic frameworks (COFs) as
immunogenic cell death (ICD) inducers for cancer immunotherapy. Three triple-topic amine building blocks, inactive to inducing
ICD, were used to construct three COFs, COF-607, COF-608, and COF-609, with outstanding ICD eliciting effiffifficiency. Mechanism
studies revealed that after linking these ICD inert monomers into the COF backbone, the optical properties of these COFs could be
systematically tuned to achieve excellent reactive oxygen species (ROS) production performance. This combined with 3D cross
linked pores, mimicking lung structure, favor the exchange and diffffusion of oxygen and ROS, leading to excellent inducing ICD
effiffifficacy. One member, COF-609, is capable of triggering abscopal and long-lasting immune memory effffects in a mouse model of
breast cancer with >95% mice survival after being treated with COF-609+αCD47 for 110 days.

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